Cenocide Diethyl Carbamazine Citrate Tablet

Cenocide®

 

COMPOSITION

Each white tablet coded SKGA3A is scored and contains: Diethyl Carbamazine Citrate B.P. 50mg

 

MODE OF ACTION

Diethyl Carbamazine Citrate is a first-line agent for the control and treatment of Lymphatic Filariasis and for the treatment of tropical pulmonary Eosinophilia. Microfilaria forms of susceptible Filariasis species (e.g. W. bancrofti, B. malayi ana L. loa) are rapidly cleared from the blood. The drug has two mechanisms of action; (a) It decreases the muscular activity end eventually immobilizes the organisms thereby dislocating them. (b) It produces alterations in the microfilarial membrane thus rendering it more susceptible to destruction by host defence mechanisms.

 

INDICATIONS

It is used in the treatment of Filarial infections. It is indicated in infections caused by W. bancrofti, B. malayi and B. timori. It is the best available drug for the treatment of Loiasis caused by Loa loa. It is also indicated in toxocariasis.

 

PRECAUTIONS

-Cenocide should not be given to pregnant women. Absolute caution should be taken when administering the drug to the elderly and the debilitated especially those with cardiac or renal diseases. In the event of severe hypersensitivity reaction, administration of a corticosteroid e.g. Bethamethasone is recommended.

 

SIDE EFFECTS

These may include nausea, vomiting, headache, dizziness and drowsiness. However these reactions are rarely severe and usually disappear within a few days despite continuation of therapy.

Major hypersensitivity reactions could occur as a result of host responses to destruction of parasites (Microfilariae). Encephalitis may be exacerbated in patients with Loiasis.

 

DOSAGE

The dosage for adults and children is the same. The starting dose is 1mg/kg body weight/day given in 3 divided doses on the first day. The dosage is increased over the next 2-3 days to 6mg/kg body weight/day in three divided doses.

Full dosage should be maintained for 21 days.

 

PRESENTATION

Cenocide is presented in a bulk pack of 100 tablets and 1000 tablets.

 

Manufactured in Nigeria by

SKG – Pharma Limited

7/9 Sapara Street,

Ikeja, Lagos.

 

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