Chloramphenicol Capsules B.P. 250mg
Each capsule contains Chloramphenicol BP 250mg
The chloramphenicol are bacteriostatic antibiotics with a wide spectrum of activity and have been used in the treatment of a large number of infections caused by susceptible organisms. With the emergence of bacterial resistance and the development of other antibacterials their use has become more restricted, but they remain the usual drugs of choice in rickettsial infections, including ehrlichiosis, typhus, spotted fevers, trench fever, and Q fever, chlamydial infections, including psittacosis, lymphogranuloma venereum, trachoma, non-gonococcal urethritis, chiamydial conjunctivitis, and pharyngitis, sinusitis, or pneumonia due to Chlamydia pneumoniae; and mycoplasmal infections, especially pneumonia caused by Mycoplasma pneumoniae. etc.
Contraindicated in patients with pregnancy and lactients.
Children under 8 years or age should not be Treated.
DOSAGE AND ADMINISTRATION
The usual adult dosage of chloramphenicol hydrochloride is 250 or 500 mg every 6 hours by mouth, preferably one hour before or 2 hours after meals.
Children in dose of 25 to 50 mg/kg up 3-4 Times daily.
The absorption of the chloramphenicol is reduced by divalent and trivalent cations such as aluminium, bismuth, calcium, iron, magnesium, and zinc, and therefore concomitant administration of chloramphenicol with antacids, iron preparations, some foods such as milk and dairy products, or other preparations containing such cations, whether as active ingredients or excipients, may result in subtherapeutic serum concentrations of the antibacterial. Sodium bicarbonate, colestipol, and kaolin-pectin are also reported to reduce chloramphenicol absorption, but potential reductions due to cimetidine or sucralfate are probably of little clinical significance, etc.
The side-effects of chloramphenicol are common to all chloramphenicol. Gastro-intestinal effects including nausea, vomiting, and diarrhoea are common especially with high doses and most are attributed to irritation of the mucosa. Other effects that have been reported include dry mouth, glossitis and discoloration of the tongue, stomatitis, and dysphagia. Oesophageal ulceration has also been reported, particularly after ingestion of capsules or tablets with insufficient water at bedtime.etc.
Yangzhou No.3 Pharmaceutical Co. Ltd.
51, Guotai Road, YiIing Town, Jiangsu, China
EMBASSY PHARMACEUTICALS AND CHEM. LTD.
Lagos – Nigeria.