(Ampicillin) Broad Spectrum Antibiotic
Cikacillin is a semi synthetic broad-spectrum penicillin which is effective against many gram positive and gram negative micro-organisms but does not act against staphylococci resistant to penicillin. It is relatively stable in the acid gastric secretion, well, absorbed from the digestive tract and reaches an appropriate concentration in the organism. Due to its broad spectrum of action, non-toxicity, small effect on intestinal fibre, good enteral absorption and sufficient concentrations in tissues and body fluids, cikacillin is very suitable for the treatment of various infections in all age groups.
ABSORPTION AND EXCRETION
Cikacillin is relatively acid suitable in gastric secretion and well-absorbed following oral administration, producing high serum and urine concentrations. In patients with normal renal functions, higher and more prolonged levels may be achieved by the concurrent administration of probenecid.
Cikaclilin is especially indicated in:
Infections of genitourinary tract.
Infections of the respiratory tract.
Infections of the digestive tract caused by various strains of shigella and salmonella.
Infections of the skin and soft tissues.
Infections due to susceptible organisms.
Side affects manifest as allergic reactions, most frequently in form of skin rash, pruritis and urticaria. Digestive disorders such as epigastric pains, vomiting and diarrhoea may occur. These side effects are usually of mild transitional nature.
DOSAGE AND ADMINISTRATION
Cikacillin should be taken ½ – 1 hour before meals.
Children: up to 2 years ½ teaspoonful 4 times daily.
2 to 6 years 1 teaspoonful 4 times daily.
6 to 12 years 1½ teaspoonful 4 times daily or as directed by a physician.
Capsule: One capsule: 4 times daily or as directed by physician.
PREPARATION OF THE SUSPENSION
To make 100ml of the suspension, add 72ml of boiled and cooled water, invert and shake the bottle until all powder is dispersed. Alternatively, gradually add boiled and cooled water to half of the bottle, shake well and slowly add more up to the mark on the label.
SHAKE WELL BEFORE TAKING EACH DOSE
The dry powder should be stored below 25°C. The suspension should be used within 7 days of preparation and stored in a cool place preferably in a refrigerator.
Cikacillin is contraindicated in patients hypersensitive to penicillin and cephalosporin.
Prior to initiation of treatment with Cikacillin, It has to be established whether the patient has had hypersensitive reactions to penicillin or cephalosprin. In prolonged treatment special attention ought to be given to symptoms of superinfection from penicillin resistant micro-organisms.
COMPOSITION AND AVAILABILITY
SUSPENSION 125mg/5ml of Ampicillin as the Trihydrate BP in 100ml bottles.
CAPSULES: 250mg, Ampicillin capsules as the trihydrate BP in packs 1000.
250mg Ampicillin capsules as the trihydrate BP in blisters of 10’s.
Michelle Laboratories Ltd.
Plot 23, Block 2, Thinkers Corner
Industrial Layout, Enugu,
Enugu State, Nigeria.