Cosamid Plus Glucosamine and Chondroitin Sulphate Capsule

HOVID COSAMID PLUS

Cosamid Plus manufactured by Hovid contains Glucosamine Sulphate 250 mg and Chondroitin Sulphate 200 mg. Glucosamine Sulphate and Chondroitin Sulphate are substances found naturally in the body.

 

ACTIONS AND PHARMACOLOGY

Glucosamine possesses antiarthrosicarthrotrophic activities. It stimulates the anabolic metabolism of osteo-cartilagineous tissues via stimulation of the biosynthesis of the mucopolysaccharides (which are the essential components of the cartilage ground substances) and of the bone mesenchymal tissues. Glucosamine also acts to improve the viscosity of synovial fluid by increasing synovial fluid production, thereby providing lubricant activity.

Chondroitin sulphate is an acid mucopolysaccharide which is a constituent of most mammalian cartilaginous tissues. It contributes to the pool of glycosaminoglycans (GAGs) in cartilaginous tissue; inhibit the synovial degradative enzymes and stimulate the synthesis of GAGs and collagen by chondrocytes.

 

INDICATION

Adjunctive therapy in osteoarthritis.

 

CONTRAINDICA TIONS

Contraindicated in patients sensitive to glucosamine sulphate and chondroitin sulphate.

 

PRECAUTIONS

Cosamid Plus is not meant to replace NSAIDs in cases of intense pain, as this is a causal therapy. It is advisable to take an anti-inflammatory drug in the initial treatment of osteoarthritis together with Cosamid Plus. Because of the theoretical possibility that chondroitin sulphate may have anti-thrombotic activity, those taking warfarin and those with hemophilia should exercise caution in its use.

 

USE IN PREGNANCY AND LACTATION

To be taken under medical supervision.

 

PAEDIATRICS

Not recommended.

 

GERIATRICS

To be taken under medical supervision.

 

INCOMPATIBILITIES

None known.

 

SYMPTOMS OF OVERDOSE AND TREATMENT

None known.

 

WHAT IS OSTEOARTHRITIS?

Osteoarthritis (OA) is a degenerative joint disease that most commonly affects middle-aged and older people. This occurs equally in both sexes; however, after the age of 55, the incidence is higher in women.

OA is marked by the degeneration of joint cartilage and enlargement of bone at the joint, often accompanied by pain and stiffness. As the disease progresses, the cartilage wears out completely, causing bone to rub against bone.

While there may be occasions where no symptoms may surface, people with OA are most presented with gradual or subtle onset of deep aching joint pain (worsens after exercise, relieved by rest), joint swelling, morning stiffness and grating of joint motion.

 

GLUCOSAMINE SULPHATE AND CHONDROITIN SULPHATE

Glucosamine is a simple molecule that the body makes from sugar and uses as a major building block of cartilage. It is one of the principal substrates in the biosynthesis of glycosaminoglycans (GAGs), proteoglycans and hyaluronan, which play a central role in cartilaginous matrix assembly and are essential for maintaining the structure and functional integrity of articular cartilage. Glucosamine contribute to the unique biochemical properties of cartilaginous matrix by avidly binding water, allowing the articular cartilage in joints to absorb pressure forces.

Chondroitin Sulphate is a major component of the extracellular matrix from many connective tissues, including cartilage, bone, skin, ligaments and tendons. It is part of the proteoglycan macromolecule, responsible, together with collagen and non-collagenous glycoproteins, for giving cartilage its resiliency. It also plays a role in allowing the cartilage to resist tensile stresses during various loading conditions by giving the cartilage resistance and elasticity.

Glucosamine sulphate and chondroitin sulphate are well tolerated. Combining both compounds yields a synergistic effect because GAGs production is stimulated by glucosamine and degradation is inhibited by chondroitin sulphate. Combinations of glucosamine and chondroitin have significantly higher effect than the additive effects of the individual ingredients. Laboratory studies have demonstrated a synergistic effect when glucosamine and chondroitin sulphate are administered together to play a role in cartilage formation, repair and elasticity.

Studies conducted show favourable results of glucosamine and chondroitin relieving OA pain over a period of time. Unlike non-steroidal anti-inflammatory drugs, glucosamine and chondroitin do not-cause gastrointestinal side effects, e.g. heartburn, stomach pain, gastric and nausea.

References:

1. A. Das, Jr and T. A. Hammad, Osteoarthritis and Cartilage (2000) 8, 343-350

2. Florent Richy, et al., Arch Intern Med. 2003; 163: 1514-1522

3. H. J. Hauselmann MD, Best Practice & Research Clinical Rheumatology (2001) 15, 595-607

4. J. Y Reginster et al. Lancet 2001, vol 357, 251-256

5. Lopes Vaz A. Curr Med Ran Opin 1982; 8(3): 145-9

6. Qiu Gx, et al., Arzneimittelforschung 1998 May; 48(5): 469-74

7. Thienm, et. al., J. Rheumatol 2001 Jun; 28(6): 1347-55

 

PRODUCT DESCRIPTION

Buff opaque I Buff opaque capsule, size 0

 

RECOMMENDED DOSAGE

For mild to moderate osteoarthritis symptoms. Oral, 1 capsule 2 times daily for 6 weeks, taken 15-30 minutes before meal.

For severe osteoarthritis symptoms. Oral, 1 capsule 3 times daily for 8 weeks, taken 15-30 minutes before meal.

Maintenance therapy should be followed for 3-4 months by administration of 1 capsule twice daily.

 

SIDE EFFECTS

Gastrointestinal disturbances such as nausea and vomiting are rarely reported.

 

PACK SIZE AND PRESENTATIONS

Blister of 10 x 10’s.

 

STORAGE CONDITION

Store below 25oC. Protect from moisture.

 

DRUG INTERACTIONS

None known.

“DERIVED FROM SEAFOOD”

 

Manufactured by

HOVID Bhd. (58476-A)

121, Jalan Tunku Abdul Rahman,

30010 Ipoh, Malaysia.

www.hovid.com

info@hovid.com