Doxycap Doxycycline Hydrochloride Capsule

DOXYCAP CAPSULE

 

Description

Light green and pink capsule with “DXV 100” printed on one end and “HD” printed on the other.

 

Composition

Doxycycline hydrochloride equivalent to Doxycycline 100mg/capsule.

 

Action and Pharmacology

Doxycycline is a bacteriostatic agent with a wide range of anti microbial activity. It Interferes with bacterial protein synthesis by reversibly binding to bacterial 30S ribosomal subunit, thus preventing the binding of aminoacyl transfer-RNA to the messenger-RNA ribosom complex. Doxycycline is readily absord from the gastro-intestinal tract and is excreted mainly in urine.

 

Indications

• Rickettsial infections, including typhus, Rocky Mountain spotted fever and Q fever.

• Chlamydial infections, including psittacosis, lymphogranuloma venereum, trachoma and inclusion conjunctivitis.

• Mycoplasma infections, especially those caused by Mycoplasma pneumoniae.

• Brucellosis and plague (use in association with streptomycin).

• Tularaemia, chronic bronchitis chancroid, granuloma inguinale, urinary tract infections, acne.

• Malabsorption syndromes such as tropical spruce and Wipple’s disease.

• Cholera, relapsing fever, leptospirosis and early stage of Lyme disease.

• Balantidiasis, amoebic dysentery (use in association with an amoebicide).

• Syphilis, yaws, gonorrhoea, actinomycosis, anthrax, rat bite fever and acute necrotising ulcerative gingivitis.

 

Contraindications

• Avoid in patients who have shown hypersensitivity to tetracyclines.

• Use is not recommended during the last half of pregnancy, nursing mothers and children under the age of 8 years as tetracyclines may cause permanent discolouration of the teeth, enamel hypoplasia and inhibition of linear skeletal growth.

 

Precautions

• Care must be taken when liver function is impaired.

• May interfere with some diagnostic tests including determination of urine catecholamines or glucose.

• Unsafe in patients with porphyria.

 

Main Side/Adverse Effects

• Nausea, vomiting and diarrhoea.

• Discoloration of Infant’s or children’s teeth.

• Cramps or burning of the stomach.

• Sore mouth or tongue (fungal overgrowth, hypertrophy of the papilla).

• Increased sensitivity to sunlight.

• Itching of the rectal or genital areas.

• Hepatotoxicity.

• Leukocytosis, neutropenia, leukopenia, atypical lymphocytes, toxic granulation of granulocytes, haemolytic anaemia, thrombocytopenia and thrombocytopenic purpura has occured.

 

Drug Interactions

• Alkalis, aluminium hydroxide, calcium, iron and magnesium diminish the absorption of doxycycline.

• Concurrent use with penicillin, barbiturates, carbamazepine, phenytoin and sodium bicarbonate is not recommended.

• Hepatotoxic and nephrotoxic drugs should not be given with doxycycline.

 

Overdosage

Clinical features: Nausea, anorexia, diarrhoea, perianal itching, skin eruption, fever, anaphylaxis and liver damage.

Treatment: Emesis or gastric lavage, if appropriate; with the necessary emergency measures, if required.

 

Dosage and Administration

Adults: Oral, 200 mg on the first day, then 100 mg once a day.

Acne: Oral, 50 mg for 6 – 10 weeks.

Note: Effect of doxycycline on teeth should be considered. Therapy should be continued for at least 10 days in group A beta-haemolytic streptococcal infections.
The information given here is limited. For further information consult your doctor or pharmacist.

 

Storage

Store below 25oC. Protect from light and moisture.

 

Presentation/Packing

Capsule 100mg x 1000’s, 250’s; Blisters of 10 x 10’s.

(Not all presentations available locally).

 

Manufactured/Batch Released by

HOVID Bhd., 121, Jalan Tunku Abdul Rahman, 30010 lpoh, Malaysia.

Revision date March 2014

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