Light green and pink capsule with “DXV 100” printed on one end and “HD” printed on the other.
Doxycycline hydrochloride equivalent to Doxycycline 100mg/capsule.
Action and Pharmacology
Doxycycline is a bacteriostatic agent with a wide range of anti microbial activity. It Interferes with bacterial protein synthesis by reversibly binding to bacterial 30S ribosomal subunit, thus preventing the binding of aminoacyl transfer-RNA to the messenger-RNA ribosom complex. Doxycycline is readily absord from the gastro-intestinal tract and is excreted mainly in urine.
• Rickettsial infections, including typhus, Rocky Mountain spotted fever and Q fever.
• Chlamydial infections, including psittacosis, lymphogranuloma venereum, trachoma and inclusion conjunctivitis.
• Mycoplasma infections, especially those caused by Mycoplasma pneumoniae.
• Brucellosis and plague (use in association with streptomycin).
• Tularaemia, chronic bronchitis chancroid, granuloma inguinale, urinary tract infections, acne.
• Malabsorption syndromes such as tropical spruce and Wipple’s disease.
• Cholera, relapsing fever, leptospirosis and early stage of Lyme disease.
• Balantidiasis, amoebic dysentery (use in association with an amoebicide).
• Syphilis, yaws, gonorrhoea, actinomycosis, anthrax, rat bite fever and acute necrotising ulcerative gingivitis.
• Avoid in patients who have shown hypersensitivity to tetracyclines.
• Use is not recommended during the last half of pregnancy, nursing mothers and children under the age of 8 years as tetracyclines may cause permanent discolouration of the teeth, enamel hypoplasia and inhibition of linear skeletal growth.
• Care must be taken when liver function is impaired.
• May interfere with some diagnostic tests including determination of urine catecholamines or glucose.
• Unsafe in patients with porphyria.
Main Side/Adverse Effects
• Nausea, vomiting and diarrhoea.
• Discoloration of Infant’s or children’s teeth.
• Cramps or burning of the stomach.
• Sore mouth or tongue (fungal overgrowth, hypertrophy of the papilla).
• Increased sensitivity to sunlight.
• Itching of the rectal or genital areas.
• Leukocytosis, neutropenia, leukopenia, atypical lymphocytes, toxic granulation of granulocytes, haemolytic anaemia, thrombocytopenia and thrombocytopenic purpura has occured.
• Alkalis, aluminium hydroxide, calcium, iron and magnesium diminish the absorption of doxycycline.
• Concurrent use with penicillin, barbiturates, carbamazepine, phenytoin and sodium bicarbonate is not recommended.
• Hepatotoxic and nephrotoxic drugs should not be given with doxycycline.
Clinical features: Nausea, anorexia, diarrhoea, perianal itching, skin eruption, fever, anaphylaxis and liver damage.
Treatment: Emesis or gastric lavage, if appropriate; with the necessary emergency measures, if required.
Dosage and Administration
Adults: Oral, 200 mg on the first day, then 100 mg once a day.
Acne: Oral, 50 mg for 6 – 10 weeks.
Note: Effect of doxycycline on teeth should be considered. Therapy should be continued for at least 10 days in group A beta-haemolytic streptococcal infections.
The information given here is limited. For further information consult your doctor or pharmacist.
Store below 25oC. Protect from light and moisture.
Capsule 100mg x 1000’s, 250’s; Blisters of 10 x 10’s.
(Not all presentations available locally).
Manufactured/Batch Released by
HOVID Bhd., 121, Jalan Tunku Abdul Rahman, 30010 lpoh, Malaysia.
Revision date March 2014