Doxycap Doxycycline Hydrochloride Capsule




Light green and pink capsule with “DXV 100” printed on one end and “HD” printed on the other.



Doxycycline hydrochloride equivalent to Doxycycline 100mg/capsule.


Action and Pharmacology

Doxycycline is a bacteriostatic agent with a wide range of anti microbial activity. It Interferes with bacterial protein synthesis by reversibly binding to bacterial 30S ribosomal subunit, thus preventing the binding of aminoacyl transfer-RNA to the messenger-RNA ribosom complex. Doxycycline is readily absord from the gastro-intestinal tract and is excreted mainly in urine.



• Rickettsial infections, including typhus, Rocky Mountain spotted fever and Q fever.

• Chlamydial infections, including psittacosis, lymphogranuloma venereum, trachoma and inclusion conjunctivitis.

• Mycoplasma infections, especially those caused by Mycoplasma pneumoniae.

• Brucellosis and plague (use in association with streptomycin).

• Tularaemia, chronic bronchitis chancroid, granuloma inguinale, urinary tract infections, acne.

• Malabsorption syndromes such as tropical spruce and Wipple’s disease.

• Cholera, relapsing fever, leptospirosis and early stage of Lyme disease.

• Balantidiasis, amoebic dysentery (use in association with an amoebicide).

• Syphilis, yaws, gonorrhoea, actinomycosis, anthrax, rat bite fever and acute necrotising ulcerative gingivitis.



• Avoid in patients who have shown hypersensitivity to tetracyclines.

• Use is not recommended during the last half of pregnancy, nursing mothers and children under the age of 8 years as tetracyclines may cause permanent discolouration of the teeth, enamel hypoplasia and inhibition of linear skeletal growth.



• Care must be taken when liver function is impaired.

• May interfere with some diagnostic tests including determination of urine catecholamines or glucose.

• Unsafe in patients with porphyria.


Main Side/Adverse Effects

• Nausea, vomiting and diarrhoea.

• Discoloration of Infant’s or children’s teeth.

• Cramps or burning of the stomach.

• Sore mouth or tongue (fungal overgrowth, hypertrophy of the papilla).

• Increased sensitivity to sunlight.

• Itching of the rectal or genital areas.

• Hepatotoxicity.

• Leukocytosis, neutropenia, leukopenia, atypical lymphocytes, toxic granulation of granulocytes, haemolytic anaemia, thrombocytopenia and thrombocytopenic purpura has occured.


Drug Interactions

• Alkalis, aluminium hydroxide, calcium, iron and magnesium diminish the absorption of doxycycline.

• Concurrent use with penicillin, barbiturates, carbamazepine, phenytoin and sodium bicarbonate is not recommended.

• Hepatotoxic and nephrotoxic drugs should not be given with doxycycline.



Clinical features: Nausea, anorexia, diarrhoea, perianal itching, skin eruption, fever, anaphylaxis and liver damage.

Treatment: Emesis or gastric lavage, if appropriate; with the necessary emergency measures, if required.


Dosage and Administration

Adults: Oral, 200 mg on the first day, then 100 mg once a day.

Acne: Oral, 50 mg for 6 – 10 weeks.

Note: Effect of doxycycline on teeth should be considered. Therapy should be continued for at least 10 days in group A beta-haemolytic streptococcal infections.
The information given here is limited. For further information consult your doctor or pharmacist.



Store below 25oC. Protect from light and moisture.



Capsule 100mg x 1000’s, 250’s; Blisters of 10 x 10’s.

(Not all presentations available locally).


Manufactured/Batch Released by

HOVID Bhd., 121, Jalan Tunku Abdul Rahman, 30010 lpoh, Malaysia.

Revision date March 2014

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