Embassy Dexamethasone Sodium Phosphate Injection

DEXAMETHASONE INJECTION

Dexamethasone Sodium Phosphate Injection

For i.m. / i.v Injection

4 mg/1 ml

 

Composition

Each ampoule of 1mI contains 4mg of dexamethasone-2 1-phosphate in the form of disodium salt.

Dexamethasone is the generic name for 9-alpha-fluoro-16-alpha-methyl-prednisolone.

 

Actions

Dexamethasone exerts a potent anti-allergic and anti-inflammatory action.

 

Indications

Severe allergic reactions (anaphylactic shock, post-transfusion reactions, acute bronchial asthma, medicamentous allergies, asthmatic condition. Stevens-Johnson syndrome, edema of larynx, acute dermatoses), adrenocortical insufficiency, acute exacerbations in patients treated with oral glucocorticoids, viral hepatitis thyroid crisis and acute thyroiditis, croup, differential diagnosis of adrenocortical hyperplasia and rumors, rheumatic diseases of joints and diseases of soft tissues.

 

Contraindications

Absolute active or cured tuberculosis, ophthalmic herpes simplex.

 

Relative

Peptic ulcer, osteoporosis, diabetes, hypertension, fresh intestinal anastomosis, diverticulitis, thrombophiebitis, inelination to psychoses, pregnancy (especially during the first trimester), renal insufficiency. Cushing’s syndrome, healing wounds, myasthenia gravis, acute and chronic infections (varticella, vaccination).

Perforation of tympanic is a contraindication to the use of solution in ear diseases.

 

Precautions

Corticosteroids may conceal symptoms of infections. Due to the risk of adrenocortical insufficiency, the treatment with steroids should not be interrupted suddenly.

Corticosteroids may induce hyperacidity and ponticulus, therefore in prolonged treatment a corresponding diet and application of antiacids are required. In gastric disorders and in prolonged treatment and X-ray control is required. Latent diabetes mellitus occurs faster.

Do not inject into the deltoid muscle because of the danger of tissue atrophy. It should not be injected locally into the infected region or intravertebral space. During pregnancy, the glucocorticoids may be applied exceptionally only, i.e. in extremely severe cases.

Newborns should be controlled carefully.

 

Side effects

Relative adrenocortical insufficiency, increased catabolism of proteins with negative nitrogen balance, disorder of electrolytic balance, disorders in metabolism of glucose with aggravation of diabetes, osteoporosis, spontaneous fractures of bones, aseptic necrosis of the hip, myopathies, activation and aggravation of peptic uncer, aggravation of infection hypertension, moon-shaped face, hirsutism, acne, abdominal striae, convulsions petechiae and purpura amenorrhea, insomnia, mental disorders, increased intraocular pressure, pancreatitis, anglitis, disorders in children’s growth, thrombophlebitis, vertigo, nausea, facial erythema, ulcerous esophagitis, headache, exophthalmos, leukoecytosis, lymphopenia, corneal ulcer oligospermia and systemic fat emboli, abnormal euphoria, increase in appetite and body weight, tissue atrophy hypopigmentation of skin, post-injection swelling, reactions similar to shock.

 

Dosage and Administration

The dosage should be adjusted to individual case. If the drug has been given longer than for a couple of days, the dose should be diminished slowly and the drug should not be discontinued immediately. It may be injected intravenously, intramuscularly, intrasynovial, or by local tissue infiltration.

Initial dose: 1 to 5 or even 20 ampoules daily (i.v. or i.m) followed by a maintenance dose of ½ to 1 ampoule several times daily.

Intrasynovial: ½ to 1 ampoule every 24 hours.

Chronic diseases: Initial treatment at a dose of 0.5 to 1mg daily with a slow increase until clinical effect is observed. Later on the drug is given twice daily.

 

Availability

On physician’s prescription only.

 

Presentation

Boxes 25 ampoules of 1 ml, or boxes 100 ampoules of 1 ml or boxes 10 ampoules of 1 ml.

 

Manufactured by

JIANGSU YIXING FORWARD PHARMAC FACTORY.

CHAN BU. YIXING ECO. DEVPT ZONE. JIANGSU PROVINCE CHINA.

 

Sole Agent

EMBASSY PHARMACEUTICAL & CHEMICALS LTD.

Lagos – Nigeria.

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