Doxycycline Capsules 100mg
Each capsule contains doxycycline 100mg
DOXYCYCLINE is a tetracycline derivative with uses similar to those of tetracycline. It is more active than tetracycline against many bacterial species including the enterococci and various anaerobes. Cross-resistance is common although some tetracycline – resistant Staphylococcus aureus respond to DOXYCYCLINE. DOXYCYCLINE is also reported to be more active against protozoa, particularly Plasmodium spp. It may sometimes be preferred to other tetracyclines in the treatment of sensitive infections because of its fairly reliable absorption and its long half-life which permits less frequent (often or daily) dosage.
Contraindicated in patients with pregnancy and laetients. Children under 8 years of age should not be treated.
DOSAGE AND ADMINISTRATION
The usual dose is 200 mg of DOXYCYCLINE on the first day (as a single dose or 100mg repeated after 12 hours), followed by 100 mg daily. Older children weighing 45 kg or less may be given 4mg per kg body – weight initially and thereafter 2mg per kg daily but the effect of tetracycline on teeth and bones should be considered.
DOXYCYCLINE has a lower affinity for binding with calcium than many tetracyclines. In consequence its absorption is less likely to be affected by milk or food, although it is still affected by antacides and iron preparations. The metabolism of DOXYCYCLINE may be accelerated by drugs that induce hepatic enzymes such as alcohol (chronic use) antiepileptics including carbamazepine, phenobarbitone, and phenytoin; and rifampicin.
It has been suggested that DOXYCYCLINE could increase cyclosporin concentrations, but evidence for this seems to be scant.
Gastro-intestinal effects including nausea, vomiting, and diarrhoea are common especially with high doses and most are attributed irritation of the mucosa. Other effects that have been reported include dry mouth, glossitis and discoloration of the tongue, stomatitis, and dysphagia. Oesophageal ulceration has also been reported, particularly after ingestion of capsules or tablets with insufficient water at bedtime, gastro-intestinal disturbances are reported to be less frequent than with tetracycline and DOXYCYCLINE may also cause less tooth discoloration etc.
NAFDAC Reg. No.: A4-0601
Yangzhou No.3 Pharmaceutical Co., Ltd.
Address: No. 51 Guotai Road, Yiling Town,
Jiangdu City, Jiangsu.
EMBASSY PHARMACEUTICAL & CHEMICALS LTD.
Lagos – Nigeria