Ibuprofen Tablets BP 400mg
Each sugar coated tablet contains:
Ibuprofen BP 400mg
Aproved colour used
Ibuprofen acts by inhibiting the activity of enzyme cyclo-oxygenase, resulting in decreased formation of precursors of prostaglandins and thromboxanes from arachidonic acid.
Ibuprofen is Indicated for the treatment of rheumatic diseases such as:
• Rheumatoid arthritis
• Ankylosing spondylitis
• Juvenile rheumatoid arthritis
For the relief of mild to moderate pain especially when anti-inflammatory actions may also be desired e.g., following dental or obstetric surgery, and for relief of musculoskeletal pain due to soft tissue athletic injuries (strains or sprains). For the relief of pain and inflammation of acute gouty arthritis. In the treatment of painful non-rheumatic inflammatory conditions such as athletic injuries, bursitis, capsulitis, synovitis, tendinitis or tenosynovitis. For reduction of fever. For the relief of pain associated with primary dysmenorrhoea.
Except under special circumstances this medication should not be used when the following medical problems exist:
• History of severe allergic reaction such as anaphylaxis or angioedema, induced by aspirin or other NSAIDs. Because of the possibility of cross-sensitivity due to structural relationship which exists among non-steroidal anti-inflammatory medicines, acute allergic reactions are likely to occur in patients who have exhibited allergic reactions to these compounds.
• Aspirin-induced nasal polyps associated with bronchospasm (high risk of severe allergic reactions because of cross sensitivity).
• Children under the age and 2 years.
• Active peptic ulceration.
• Safety in pregnancy and lactation has not been established.
Tachycardia, flushing, increase in blood pressured.
Central nervous system
Confusion, hallucinations, mental depression, peripheral neuropathy, tinnitus, drowsiness; insomnia.
Epigastric pain or discomfort, gastritis, haematemesis, gastro-intestinal perforation, gastro-intestinal ulceration.
Allergic dermatitis, erythema multiforme, Stevens- Johnson Syndrome, toxic epidermal necrolysis.
Haematuria, cystitis, renal impairment or failure, polyuria, fluid retention/oedema, acute renal failure, interstitial nephritis, nephrotic syndrome.
granulocytosis, anaemia, aplastic anaemia, eosinophilia, haemolytic anaemia, leukopeania, thrombocytopaenia.
Angiitis, angioedema, bronchospastic allergic reactions, allergic rhinitis, serum sickness like reaction, systemic lupus erythematosus, aseptic meningitis.
Amblyopia, blurred or double vision, conjunctivitis, dry irritated or swollen eyes, scotomata.
Aphthous stomatitis, gingival ulcerations.
Ear, Nose and Throat
Decreased hearing or any change in hearing, epistaxis.
Dosage and Direction for Use
Usual adult dose
Adults: The recommended dosage is 1200 mg daily in divided doses. In severe cases the initial dose in the acute phase may be increased, until the acute phase has been brought under control.
Maximum daily dose: 2.4 g per day.
Acute gout: 2400mg daily either as 800 mg, 8 hourly or 600 mg, 6 hourly until acute symptoms have been relieved. If acute symptoms do not resolve within 3 days, consult a doctor.
Juvenile Rheumatoid Arthritis: Total daily dose is 20 mg/kg of body weight in divided doses.
Pyrexia and pain: 20 mg/kg/day in divided doses.
10 Tablets in one blister, 1 blisters pack in one carton.
Store in a cool, dry place. Protect from heat.
Keep all medicines out of reach of children.
Medico Remedies Pvt. Ltd.
8 & 9, Dewan & Sons, Udyog Nagar,
Paighar, Maharashtra – 401 404. India.
LOKEL PHARMACEUTICAL CO. LTD.
1A, Aina George Street,
Ilupeju, Lagos, Nigeria.