Hydrex Hydrochlorothiazide Tablet

HYDREX®

HYDREX (HYDROCHLOROTHIAZIDE) TABLET

 

COMPOSITION

Each tablet contains Hydrochlorothiazide B.P. 25mg.

 

DESCRIPTION

Hydrex is thiazide diuretic that increases urine excretion of sodium and water inhibiting sodium reabsorption at the beginning of the distal convoluted tubule.

Hydrex achieves onset of diuretic action within 1 to 2 hours and this is sustained for 12 to 24 hours.

 

INDICATIONS

Hydrex is indicated in the treatment of oedema and hypertension. It can be used alone or as an adjunct to other antihypertensive agents.

 

CONTRAINDICATION

Refractory hypokalemia, hyponatrameia, severe renal and hepatic impairment, Symptomatic hyperuricaemia, Addison’s disease.

 

WARNINGS AND PRECAUTION

Hydrex may cause hypokalaemia, aggravates diabetes and gout; may exacerbate systemic lupus erythematosus. It is to be used with caution in the elderly; pregnancy and breast-feeding.

Alcohol, barbiturates or narcotics when used with thiazide diuretics, orthostatic hypotension may occur.

 

ADVERSE REACTION

Postural hypotension and gastro-intestinal effects, impotence, reversible on withdrawal of treatment, hypokelaemia, hypomagnesaeia, hyponatraemia, hypercalcaeia, hypochloraemic alkalosis, hyperuricaemia, gout, hyperglycaemia and altered plasma lipid concentration; less commonly rashes, photosensitivity; blood disorders and hypersensitivity reactions.

 

DOSAGE AND ADMINISTRATION

Oedema: initially 25-50mg daily, reduced for maintenance if possible; severe oedema in patients unable to tolerate Loop diuretics, initially 75mg daily.

Hypertension: 25mg of Hydrex daily, increased to 50mg daily if necessary.

Elderly: In some patients (especially the elderly) an initial dose of 12.5mg daily may be sufficient.

 

PRESENTATION

Hydrex tablets are scored, white and round with HCT\25 and JHL inscribed on both faces respectively, supplied in blister packs of 100s (10 x 10 strips) and jars of 500s.

 

Keep all medicine out of reach of children.

 

Manufactured by

JUHEL NIGERIA LIMITED

35 Nkwubor Road, Emene, Enugu, Nigeria.