M&B Cipro Ciprofloxacin Caplets

(Ciprofloxacin Caplets)


PROPRIETARY NAME (and dosage form)

M & B Cipro 500mg caplets by 10’s



Each caplet contains 500mg Ciprofloxacin






Bactericidal by inhibition of DNA supercoiling in the bacteria. It accomplishes this by inhibiting the enzyme DNA gyrase. Ciprofloxacin is one of the most active fluroquinolones against Gram-negative aerobic bacteria including Enterobacteriacae e.g Salmonella, Klebsiella and Shigella species. Haemophilus, Neisseria, Campylobacter and Pseudomonas species. It is also active in vitro against many Gram-positive aerobic pathogens including penicillinase producing and methicillin-resistant Staphylococci.



M & B Cipro caplets 500mg are indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the conditions listed below.

1. Lower respiratory tract infections caused by Haemophilus influenza, H. paraininfluenzae, E. coli, Klebsiella pnuemoniae, Enterobacter cloacae, Proteus mirabilis, and Pseudomonas aeruginosa, Chlamydia and some mycobateria.

2. Urinary Tract Infection

3. Skin and Skin Structure Infections

4. Acute Uncomplicated Cystitis in females caused by Escherichia coli or Staphylococcus saprophyticus. And Chronic Bacterial Prostatitis caused by Escherichia coli or Proteus mirabilis.

5 Uncomplicated cervical and urethral gonorrhea due to Neisseria gonorrhea.



Dosage depends on the severity and nature of infection. Unless prescribed otherwise, the following doses are recommended:

Urinary Tract Infections: Mild to Moderate: 250mg twice daily. Severe: 500mg twice daily.
Lower Respiratory Tract Infections: Mild to Moderate: 500mg twice daily. Severe: 750mg twice daily.

Urethral and Cervical Gonococcal Infection: Uncomplicated: 250mg single dose. The recommended adult dosage for chronic bacterial prostatitis is 500mg twice daily. In acute uncomplicated cystitis in females, the usual dosage is 250mg twice daily.

Skin and skin structure infections may be treated with 500mg twice daily.



Hypersensitivity to the drug and other quinolones. Growing adolescents, unless benefits outweigh risks. Children below 12 years, Ciprofloxacin should not be administered to pregnant or lactating mothers.

Contra indicated in co-administration with drugs primarily metabolized by the enzyme CYPIA2 (G6PD deficiency).



Side effects may include dizziness, headache, tremor, blurred vision, convulsion, confusion, and GIT disturbances. Judgment and dexterity may be impaired. Transient increases in serum creatinine. Haemotological, hepatic and renal disturbances.



Theophylline metabolism is inhibited (Monitor theophylline levels). Concomitant administration of Ciprofloxacin with theophylline decreases the clearance of theophylline resulting in elevated serum theophylline levels and increased risk of a patient development CNS or other adverse reactions. Serum concentration reduced by antacids. Potentiates oral anticoagulants.



Ciprofloxacin should be used with caution in patients with suspected or known CNS disorders such as arteriosclerosis or epilepsy or other factors which predispose to seizures myasthenia gravis and renal impairment.

Liberal intake of water is advised during the use of ciprofloxacin.

Caution should be taken when used with products containing calcium, Iron and Zinc (See antacid interaction above). They can be taken two hours after or six hours before the drug.

Should not be used for pneumococcal pneumonia and most anerobic organism are not susceptible.



Store in a cool, dark and dry place.

Keep this medication out of the reach of children.



Ciprofloxacin 500mg caplets by 10’s.


Manufactured by

May & Baker Nigeria Plc.

1, May & Baker Avenue, Off Idiroko Road,

(Opposite Covenant University)

Ota, Ogun State, Nigeria.


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