BRAND OF PIROXICAM
Each capsule of PILOXICAM contains 20mg of Piroxicam.
PILOXICAM is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class and a non-selective COX inhibitor possessing both analgesic and antipyretic properties. It undergoes enterohepatic circulation.
MODE OF ACTION
PILOXICAM works by reducing the levels of prostaglandins in the body. It blocks cyclooxygenase which is the enzyme that produces prostaglandins. This results in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced.
PILOXICAM is effective in treating fever, pain and inflammation in the body. It is also used in veterinary medicine to treat certain neoplasias expressing cyclooxygenase receptors, such as bladder, colon and prostate cancers.
As a group, NSAIDs are non-narcotic relievers of mild to moderate pain of many causes; including injury, menstrual cramps and primary dysmenorrhoea, rheumatoid and osteo-arthritis, arthrosis, degenerative joint disease, ankylosing spondylitis, tendinitis, sprains, back pain, acute gout, post-operative paint post-traumatic pain and other musculoskeletal conditions. They act as analgesics, especially where there is an inflammatory component.
STANDARD DOSAGE AND ADMINISTRATION
Always take PILOXICAM exactly as your doctor has told you to. You should check with your doctor or pharmacist if you are not sure. Do not take more than the recommended dose. If symptoms persist for more than 3 days, consult your doctor or pharmacist.
The recommended dose is 20mg once daily or 10mg twice daily. It should be taken with food.
RHEUMATIC DISEASE IN ADULTS
Initially 20mg daily followed by a maintenance dose of 10-30mg daily in a single or divided dose.
ACUTE MUSCULOSKELETAL DISORDERS IN ADULTS
Initially 40mg daily in a single or divided dose for 2 days; then 20mg daily for 7-14days.
ACUTE GOUT IN ADULTS
Initially 40mg daily; then 40mg daily in a single or divided dose for 4-6 days.
JUVENILE ARTHRITIS IN CHILDREN OVER 6 YEARS OF AGE
Under 15kg 5mg daily
16-25kg 10mg daily
26-45kg 15mg daily
Over 46kg 20mg daily
If you have taken more PILOXICAM than has been prescribed for you or someone else accidentally ingests your medicine, immediately see a doctor or go to a hospital straight away. Take this leaflet, the remaining capsules and packet with you to the hospital or doctor so that they know which capsules were consumed.
Local treatment of overdose includes emptying of the stomach by induced vomiting or gastric lavage. Careful monitoring and supportive treatment, monitoring of renal function, and maintaining adequate hydration is recommended.
PILOXICAM use can result in gastrointestinal toxicity, abdominal pain, tinnitus, dizziness, drowsiness, nausea, constipation, fluid retention, headache, rash, and pruritus.
The most severe adverse reactions are peptic ulceration, gastrointestinal bleeding, and severe skin reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis.
In rare cases, PILOXICAM may cause the skin to become more sensitive to sunlight.
PRECAUTIONS AND WARNING
Check with your doctor or pharmacist before taking PILOXICAM because it may mask the signs and symptoms of other infections. Fluid retention and peripheral oedema may occur; so use cautiously in cardiac dysfunction, hypertension or other conditions pre-disposing to fluid retention.
PILOXICAM may prolong bleeding time; so use with caution in coagulation disorders. Discontinue therapy if abnormal liver test persists or worsens.
PILOXICAM may cause alteration in motor coordination; so counsel patients on the possible effects on driving and performance of other skilled tasks.
Do not take PILOXICAM if you:
• Are allergic or hypersensitive to piroxicam aspirin or other NSAIDs.
• Are taking other drugs that contain paracetamol.
• Are suffering from active peptic ulcer.
• Taking medicines that reduce the clotting of blood.
PREGNANCY AND LACTATION
Safety during pregnancy has not been established. The use of PILOXICAM in late pregnancy may cause premature closing of the ductus arteriosus in the fetus.
PILOXICAM is excreted into human breast milk. Use by nursing mothers is not recommended.
10 x 10 blistered capsules in one packet with a leaflet.
PILOXICAM 2Omg is a maroon-colored capsule, engraved with ‘PIL’ on one side and ‘20’ on the other side.
Keep all medicines out of the reach of children. Do not store above 25 degrees centigrade.
Protect from direct sunlight and store in a cool, dry place.
Ask your pharmacist how to dispose of medicines no longer required or have expired.
Manufactured and Marketed by
PHAMATEX INDUSTRIES LIMITED
1 Crystal Glass Close, Amuwo-Odofin,
Industrial Estate, Lagos. Nigeria.
Item code: PMLP 002-00
Dated: August 2013.