Sepox Pediatric Cotrimoxazole Suspension and Tablets

SEPOX
PAEDIATRIC CO-TRIMOXAZOLE SUSPENSION B.P. I CO-TRIMOXAZOLE TABLETS B.P.

 

1. What is SEPOX?

(A) SEPOX (PAEDIATRIC SUSPENSION)

Each 5 ml (1 teaspoonful) contains

Sulfamethoxazole B.P 200 mg.

Trimethoprim 40 mg.
(B) SEPOX TABLETS

Each uncoated tablet contains

Sulfamethoxazole B.P 400 mg.

Trimethoprim B.P 80 mg.

 

2. What is a Co-trimoxazole?

Co-trimoxazole is a mixture of 5 parts of Sulfamethoxazole (Sulpfonamide) and 1 part of Trimethoprim.

 

3. What is SEPOX for?

SEPOX contains Sulfamethoxazole and Trimethoprim which is a broad spectrum antimicrobial drug exhibiting bactericidal activity. It is very effective in pneumocystis carinii pneumonia; toxoplasmosis & nocardiosis. It is also used in the treatment of Urinary tract infections, respiratory and gastrointestinal tract infections, acute otitis media, chronic bronchitis, pharangytis, and sinusitis and travellers diarrhoea in adults.

 

4. How does SEPOX work?

As SEPOX is a combination drug, they work with a synergistic effect. They interfere with synthesis of nuclei acids in sensitive microorganism and dihydro folic acid conversion. This in turn impairs the synthesis of Amino acids.

 

5. What is the Pharmacokinetics of SEPOX (Co-trimoxazole)?

Co-trimoxazole is rapidly absorbed following oral administration. Both Sulfamethoxazole and Trimethoprim reach the plasma concentration in 2-4 hours respectively.

Sulfamethoxazole also exists as conjugated form. Approximately 70 % of Sulfamethoxazole and 44 % of Trimethroprim are bond to plasma Proteins.

Sulfamethoxazole inhibits bacterial synthesis of dihydro folio acid. Trimethoprim blocks the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the required enzyme dihydrofolate reductase. Thus co-trimoxazole blocks two vital steps in the biosynthesis of nucleic acid and proteins essential for bacteria.

 

6. What are the Side effects and Precautionary measures while taking SEPOX?

The most common side effects are Nausea (with or without vomiting), anorexia gastrointestinal disturbances and allergic skin reactions (such as rash and urticaria) Dermatitis, dizziness, drowsiness, fatigue, headache, insomnia are sometimes seen.

SEPOX should not be given to patients with history of hypersensitivity to Co-trimoxazole. It should be discontinued at the first appearance of skin rash and take doctor advice. It is contraindicated in patients with renal or hepatic failure or blood disorders. People with glucose-6-phosphate dehydrogenase deficiency should avoid Co-trimoxazole. Use of SEPOX in pregnancy should be through Physicians guidance only. Co-trimoxazole tablets should not be given to infants below 6weeks.

 

PATIENT ADVICE

Adequate fluid intake is necessary to reduce the risk of crystalluria.
Take at regular intervals. Complete the prescribed course unless otherwise directed.

 

7. What is the Dosage of SEPOX?

GROUP AGE DOSAGE (SUSPENSION)
PAEDIATRIC 6 weeks to 5 Months Half teaspoonful (2.5ml) every 12 hours
6 Months to 5 Years One teaspoonful (5ml) every 12 hours
6 Years to 12 Years Two teaspoonful (10ml) every 12 hours
DOSAGE (TABLETS)
PAEDIATRIC 6 Years to 12 Years One tablet every 12 hours
ADULTS Over 12 Years and above Two tablets every 12 hours
OR AS DIRECTED BY PHYSICIAN


8. What are the
available pack sizes or SEPOX?

Bottle of 50 ml.

Pack of 1000 tablets in a jar.

Pack of 100 tablets in a jar.

Monocarton of 10 Blisters of 10 tablets.

 

9. What are the storage conditions for SEPOX?

The Paediatric Co-trimoxazole Suspension and Co-trimoxazole Tablets should be stored below 25oC in dry place protected from light. Keep all medicaments out of reach of children.

 

Manufactured in Nigeria by

DANA PHARMACEUTICALS LIMITED

Shiroro Dam Road, Post Box No. 3195,

Maitumbi, Minna, Niger State, Nigeria.

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