Artesun Artesunate Sodium Bicarbonate and Sodium Chloride Injection


Artesunate for Injection






Each Artesun 30mg box contains 1 vial of 30mg artesunate powder for solution for injection, 1 ampoule of 0.5 ml sodium bicarbonate 50 mg/ml solution for injection and 1 ampoule of 2.5mi sodium chloride 9mg/mi solution for injection.

Each Artesun 60mg box contains 1 vial of 60 mg artesunate powder for solution for injection, 1 ampoule of 1 ml sodium bicarbonate 50mg/ml solution for injection and 1 ampoule of 5 ml sodium chloride 9mg/ml solution for injection.

Each Artesun 120mg box contains 1 vial of 120mg artesunate powder for solution for injection, 1 ampoule of 2 ml sodium bicarbonate 50mg/ml solution for injection and 1 ampoule of 10 ml sodium chloride 9 mg/ml solution for injection.



Artesunate for injection: White crystalline powder

Solvent (sodium bicarbonate injection): Clear, colourless liquid

Solvent (sodium chloride injection): Clear, colourless liquid



4.1 Therapeutic indication

Artesun, administered intravenously or intramuscularly, is indicated for the treatment of severe malaria caused by Plasmodium falciparum, in adults and children.


4.2 Posology and method of administration


Adults and children weighing 20kg or more: Artesun is administered at a dose of 2.4 mg of artesunate / kg body weight by intravenous (IV) or intramuscular (IM) injection, at 0.12 and 24 hours, then once daily until oral treatment can be substituted.

Children weighing less than 20 kg: Artesun is administered at a dose of 3 mg of artesunate / kg body weight, by intravenous (IV) or intramuscular (IM) injection, at 0.12 and 24 hours, then once daily until oral treatment can be substituted (see section 5.1).


Method of administration

Artesun should be administered for a minimum of 24 hours (3 doses), regardless of the patient’s ability to tolerate oral medication earlier. After at least 24 hours of Artesun, and when able to tolerate oral medication, the patient should be switched to a complete treatment course of an oral combination antimalarial regimen.


Because of the instability of artesunate in aqueous solutions the reconstituted solution must be used within one hour of preparation. Therefore the required dose of artesunate should be calculated and the number of vials of artesunate needed should be determined prior to reconstitution of the artesunate powder.

Reconstitution of the artesunate solution

Using a syringe, withdraw the supplied sodium bicarbonate solvent from the ampoule and inject into the vial containing the artesunate powder. Shake the vial for several minutes to mix well until the powder is completely dissolved and the solution is clear. If the solution appears cloudy or a precipitate is present, it should be discarded. The reconstituted artesunate solution should always be used immediately, and discarded if not used within one hour.

Following reconstitution the solution must be diluted according to the method of injection, as described below.

For intravenous (IV) injection

Using a syringe, add the supplied sodium chloride 0.9% for injection solvent to the vial containing the reconstituted artesunate solution. This will yield a solution containing artesunate 10 mg/ml. Shake to mix well, ensuring that the resulting solution is still clear, if the solution appears cloudy or a precipitate is present, it should be discarded.

The volume required will be equal to: (desired dose in mg)/10 ml
Withdraw the required volume of artesunate solution from the vial with a syringe and then inject slowly intravenously, over 1-2 minutes.

Artesun should NOT be administered as an intravenous drip.

For intramuscular (IM) injection

Using a syringe, add to the vial containing the reconstituted artesunate solution the following volume of the supplied sodium chloride 0.9% for injection solvent: 1 ml for Artenun 30mg, 2 ml for Artesun 60mg or 4 ml for Artesun 120mg. This will yield a solution containing artesunate 20 mg/ml. Shake to mix well, ensuring that the resulting solution is still clear. If the solution appears cloudy or a precipitate is present, it should be discarded.

The volume required will be equal to: (desired dose in mg)/20 ml.

Withdraw the required volume of artesunate solution from the vial with a syringe and then inject intramuscularly; the anterior thigh is usually the preferred site for injection. If the total volume of solution to be injected intramuscularly is large, it may be preferable to divide the volume and inject it at several sites, e.g. both thighs. Do not use water for injection for reconstitution of the artesunate powder or for dilution of the resulting solution prior to injection.

Hepatic and renal impairment

Dose adjustment is not necessary in patients with hepatic or renal impairment (see Sections 4.4 and 5.2).


4.3 Contraindications

Artesun is contraindicated in patients with hypersensitivity to artesunate or other artemisinins.


4.4 Special warnings and precautions for use

Non-falciparum malaria

Artesunate has not been evaluated in the treatment of severe malaria due to Plasmodium vivax, Plasmodium malariae or Plaornodiam ovale.

Resistance to antimalarials

Local information on the prevalence of resistance to antimalarials should be considered in choosing the appropriate combination antimalarial regimen for use with Artesun (see sections 4.2).

Post-treatment haemolytic anaemia

Delayed haemolytic anaemia following treatment with injectable artesunate has been observed in children in malaria endemic areas and in non-immune travellers presenting with severe faiciparum malaria. The risk was most pronounced in patients with hyperparasitaemia and in younger children. Some cases have been severe and required blood transfusion. Vigilance for delayed onset anaemia is therefore advised, particularly in hyperparasitamic patients and younger children, and prolonged follow-up should be considered (e.g. 14-28 days).

Hepatic/renal impairment

Data regarding artesunate pharmacokinetics in patients with hepatic and/or renal impairment are limited. Based on data from studies in patients with severe malaria, as well as the known metabolism of artesunate (see Section 5.2), dosage adjustment is not considered necessary in patients with hepatic or renal impairment.

Paediatric population

In clinical trials, the efficacy and safety of intravenous and intramuscular artesunate have been similar in adult and paediatric populations.

There is no clinical data available for infants weighing below 5kg and adults weighing over 100kg.


4.5 Interaction with other medicinal products and other forms of interaction

Artesunate is rapidly and extensively converted to dihydroartemisinin (DHA), the active metabolite, primarily by plasma and erythrocyte esterases. DHA elimination is also rapid (half-life approximately 45 min) and the potential for drug-drug interactions appears limited. In ultra drug-interaction studies have demonstrated minimal effects of artesunate on cytochrome P450 isoenzymes. Few clinical drug-drug interaction studies have been performed, however no clinically significant interactions have been identified.


4.6 Pregnancy and lactation


Severe malaria is especially hazardous during pregnancy, therefore full dose parenteral artesunate treatment should be administered at any stage of pregnancy without delay, in animal studies, artesunate has been associated with fetal toxicity during the first trimester of pregnancy. Limited clinical experience with the use of artesunate in the first trimester of pregnancy as well as clinical data from more than 2,500 pregnant women, predominantly treated with artesunate in the second and third trimester, do not indicate adverse effects of artesunate on pregnancy or on the health of the fetus/newborn child.


Limited information indicates that dihydroartemisinin, the active metabolite of artesunate, is present at low levels in breast milk. The drug levels are not expected to cause any adverse effects in breastfed infants. The amount of drug present in breast milk does not protect the infant from malaria.


4.7 Effects on ability to drive and use of machines

There is no information on the effect of artesunate on the ability to drive or use machines. The patient’s clinical status should be considered when assessing ability to drive or operate machinery.


4.8 Undesirable effects

The most important reported side effect of artesunate is a rare severe allergic reaction (estimated risk approximately 1 in 3000 patients), which has involved urticarial rash as well as other symptoms, including hypotension, pruritus, oedema, and/or dyspnoea.
More common minor side effects associated with IV administration have included dizziness, light-headedness, rash, and taste alteration (metallic/ bitter taste). Nausea, vomiting, anorexia and diarrhea have also been reported, however it is uncertain whether such events have been symptoms of severe malaria. Adverse events considered at least possibly related to artesunate are listed below by body system, organ class and absolute frequency. Frequencies are defined as very common (≥1/10), common (1/100-1/10), uncommon (1/1000-1/100), rare (1/10000-l/1000), and very rare (< 1/10000).

Blood and lymphatic systems disorders

Uncommon: Neutropenia and anaemia (both occasionally severe), thrombocytopenia
Very rare: Pure red cell aplasia

Frequency unknown: Post-treatment anaemia (see below), mild and transient decrease in reticulocyte count

Nervous system disorders

Common: Dizziness, light-headedness, headache, insomnia, tinnitus (with or without decrease in auditory function)

Very rare: Peripheral neuropathy (or paraesthesia)

Respiratory disorders

Common: Cough, nasal symptoms

Gastrointestinal disorders

Common: Altered taste, nausea, vomiting, abdominal pain or cramps, diarrhoea

Rare: Raised serum amylase, pancreatitis

Hepatobiliary disorders

Uncommon: Transient rises in liver transaminases (AST, ALT)

Rare: Hepatitis

Skin and subcutaneous tissue disorders

Common: Rash, alopecia

Musculoskeletal and connective tissue disorders

Common: Arthralgia, muscle disorders

General disorders and administration site conditions

Common: Fatigue, malaise, fever, pain at injection site

Immune system disorders

Uncommon: hypersensitivity

Post-treatment anaemia

Cases of delayed haemolytic anaemia have been identified in non-immune travellers following treatment of severe malaria with injectable artesunate. Some were severe and required blood transfusions. In a study in African children aged 6 months to 10 years of age in malaria endemic areas, 5 out of 72 children (7%) experienced delayed haemolytic anaemia following treatment with injectable artesunate, and one child required transfusion, Risk was increased with hyperparasitaemia in all age groups and with younger age in children. Onset of haemolysis and anaemia was evident by 14-28 days after artesunate treatment. Vigilance for this adverse event is advised (see section 4.4)

Paediatric population

The safety profile of injectable artesunate is similar in children and adults.


4.9 Overdose

Experience of acute overdose with artesunate is limited. A case of overdose has been documented in a 5-year-old child who was inadvertently administered rectal artesunate at a dose of 88 mg/kg/day over 4 days, representing a dose more than 7-fold higher than the highest recommended artesunate dose. The overdose was associated with pancytopenia, melena, seizures, multiorgan failure and death.
Treatment of overdose should consist of general supportive measures.



5.1 Pharmacodynamic properties

Pharmacotherapeutic group: Antimalarial , ATC code: P01BE03

Mechanism of action

Artesunate is a hemisuccinate derivative of dihydroartemisinin, which is itself formed by the reduction of artemisinin. Artemisinin is a sesquiterpene lactone endoperoxide extracted from qinghao (sweet wormwood, Artemisia annua L), a plant which has been used for centuries in traditional Chinese medicine.

The mechanism of action of the artemisinins likely involves cleavage of the internal endoperoxide bridge through reaction with haeme within the infected erythrocyte, thereby generating free radicals which alkylate vital parasite proteins. However, artemisinins have also been reported to inhibit an essential parasite calcium adenosine triphosphatase.

The artemisinins are distinguished from other antimalarials by their ability to kill all erythrocytic stages of the malaria parasite, including the relatively inactive ring stage and late schizonts, as well as the gametocytes responsible for malaria transmission.

Artesunate and the artemisinins are the most rapid acting of the antimalarials, and they have also been shown to enhance splenic clearance of infected erythrocytes by reducing cytoadherence.

In vitro, dihydroartemisinin (DHA), the active metabolite of artesunate, exhibits similar potency against chloroquine-resistant and chloroquine-sensitive clones of P. falciparum.
Artesunate and the other artemisinins are essentially inactive against extra-erythrocytic forms, sporozoites, liver schizontes or merozoites.

Clinical efficacy and safety

In the SEAQUAMAT (South East Asian Quinine Artesunate Malaria Trial), an international randomised, open-label, multicenter trial conducted in Bangladesh, India, Indonesia and Myanmar, 1461 patients with severe malaria (including 1259 adults) were treated intravenously with either artesunate or quinine. Artesunate was administered at 2.4 mg/kg IV at 5, 12 and 24 h and then every 24 h until the patient could tolerate oral medication. Quinine was given IV at 20 mg/kg over 4 hours, followed by 10 mg/kg over 2-8 hours, 3 times daily until oral therapy could be started. Mortality in the artesunate group was 15% versus 22% in the quinine group, for a reduction in risk of death of 34.7% (p=0.0002). Subgroup analysis suggested a greater benefit of artesunate versus quinine in patients with parisitemia >10%. The reduction in mortality observed in the 202 paediatric patients (<15 years of age) appeared consistent with the overall results, however the number of children was too small to demonstrate statistical significance. Post-treatment hypoglycaemia was more common in the quinine-treated group.


The AQUAMAT (African Quinine Artesunate Malaria Trial) was an international, randomized open-label multicenter trial which sought to extend the results of the SEAQUAMAT study by comparing parenteral artesunate versus IV quinine for severe malaria in 5425 African children (< 15 years) in 9 African countries (Mozambique, The Gambia, Ghana, Kenya, Tanzania, Nigeria, Uganda, Rwanda, and Democratic Republic of the Congo). Dosing was similar to SEAQUAMAT, except that both artesunate and quinine could be administered either intravenously or intramuscularly, using the same doses for IM and IV administration for each drug. Roughly one third of patients received study drug by intramuscular injection. Mortality in the artesunate group was 8.5% compared to 10.9% in the quinine group, resulting in a relative risk reduction for death of 22.5% (p=0.0022); the risk reduction was similar for IV and IM administration. In addition, although the risk of neurological sequelae in survivors in both groups did not differ significantly by 28 days following treatment, in-hospital coma, convulsions, and deterioration of coma were all less frequent in the artesunate-treated patients. As in the SEAQUAMAT, post-treatment hypoglycaemia was more common in the quinine-treated group.


5.2 Pharmacokinetic properties


After intravenous injection artesunate is very rapidly biotransformed to its active metabolite, dihydroartemisinin (DHA). Consequently, artesunate half-life (t½) is estimated to be less than 5 minutes. Following a single IV dose of 2.4 mg/kg, maximum artesunate plasma concentrations (Cmax) were estimated to be 77 µmo//L in a study in Gabonese children with severe malaria, and 42 and 36 µmol/L in two studies in Vietnamese adults with uncomplicated malaria.

High concentrations of DHA are observed within 5 minutes of artesunate IV administration. In the above studies (adult and paediatric), the ranges of values for the estimated time to maximum concentration (tmax) and t½ for DHA were 0.5-15 minutes and 21-64 minutes, respectively, while DHA Cmax values ranged from 5.3-10.6 µmol/L.


Artesunate is rapidly absorbed following intramuscular injection, and peak plasma levels are generally achieved within 30 minutes of administration. Thus, after IM injection of 2.4 mg/kg of artesunate, absorption was rapid in Gabonnse children and Vietnamese adults, with Tmax values of 8 and 12 minutes, respectively. The corresponding artesunate t½ values were estimated to be 48 minutes in children and 41 minutes in adults, and Cmax values were 1.7 and 2.3µmol/L, for children and adults, respectively.

After IM injection artesunate Cmax values were therefore lower by roughly 45-fold in children and 20-fold in adults when compared to IV injection. However, rates of artesunate elimination in children and adults were 32-fold and 13-fold slower, respectively, following IM injection, compared to IV administration.


DHA has been shown to substantially accumulate in P. falciparum-infected erythrocytes. Plasma protein binding of dihydroartemisinin was determined to be 93% in patients and 88% in healthy volunteers.

Metabolism and elimination

Artesunate is extensively and rapidly hydrolysed by plasma esterases, with possible minimal contribution by CYP2A6. The main metabolite, dihydroartemisinin, accounts for most of the in viva antimalarial activity of oral artesunate, however, following IV administration, artesunate may contribute more significantly. DHA is further metabolized in the liver via glucuronidation and is excreted in the urine; ᾳ-dihydroartemisinin-β-glucuronide has been identified as the major urinary product in patients with falciparum malaria.

Special population

No pharmacokinetic data are available for patients with impaired renal or hepatic function. However, based on the known mechanisms of metabolism and elimination of artesunate, combined with clinical data from patients with severe malaria and accompanying renal and/or hepatic compromise of various degrees, no dose modifications are considered necessary in renal or hepatic impairment.


5.3 Preclinical safety data

General toxicity

Artesunate presents low acute toxicity. After repeated administration of 50 mg/kg/day in rats and 82.5 mg/kg/day in dogs, i.e. approximately 10 and 17 times the proposed maximal therapeutic dose in man, evidence of toxicity was observed in the haematopoietic organs, the immune system and response, the liver and kidneys.


Artesunate did not show any mutagenic or clastogenic potential in in vitro and in viva tests (Ames, mouse micronucleus).


No studies of the carcinogenic potential of artesunate have been conducted.

Reproductive toxicology studies

Oral artesunate caused dose-dependent foetal toxicity in rats, rabbits and monkeys, resulting in foetal resorption and abortion, as well as a low incidence of cardiac and skeletal defects. The no-observed-adverse-effect-level (NOAEL( was 12 mg/kg in pregnant monkeys (3 and 7 day exposures) and the no or low adverse effects level was 5-7 mg/kg in pregnant rats or rabbits (12 day exposures), both of which are above the therapeutic dose range (2.4-4.8 mg/kg) and expected duration of exposure for treatment of severe malaria in humans. In rats, the embryo-fetuses were most sensitive from gestational days 9-14; at other times embryotoxicity was significantly reduced.

Safety pharmacology studies

A slight sedative effect, decrease in body temperature, mild natriuresic effect and a decrease in creatinine clearance were observed with artesunate after single intravenous doses of 200 mg/kg (mice), 450 mg/kg (rats, rabbits and dogs) and following single oral doses of 180 mg/kg in male rats. Beagle dogs administered IV artesunate at 10, 20, 50, and 50 mg/kg for 14 days did not display significant clinical effects, including any signs of neurotoxicity, effects on body weight, ECG abnormalities (including QT interval changes), heart rate, blood pressure, or respiratory rate.



6.1 List of excipients

Solvent: sodium bicarbonate

Diluent: sodium chloride


6.2 Incompatibilities

In the absence of compatibility studies, this medicinal product must not be mixed with other medicinal products.


6.3 Shelf life

36 months


6.4 Special precautions for storage

Store below 30oC. Protect from light.

The reconstituted solution should be stored below 30oC and should be used within 1 hour.


6.5 Nature and contents of container

Artesunate for injection: The primary packs are colourless, type I glass vials with gray colored type I rubber stoppers and aluminium lid with a blue flip-off plastic cover.
Solvent (sodium bicarbonate injection 50mg/ml): The primary packs are colourless type I glass ampoules.

Diluent (sodium chloride injection 9mg/ml): The primary packs are colourless type I glass ampoules.

Pack size: A small box containing one vial of artesunate for injection, one ampoule of the sodium bicarbonate injection (solvent) and one ampoule of the sodium chloride injection (diluents).


6.6 Special precautions for disposal

No special requirements



Guilin Pharmaceutical Co., Ltd.,

No.43 Qilidian Road, Guilin 541004, Guangxi, China.



January 2015

Amalar Sulfadoxine and Pyrimethamine Tablets




For the use of Medical Profession, Hospital or a Laboratory only



Each tablet contains

Pyrimethamine USP 25 mg and Sulfadoxine USP 500 mg



A combination of Sulfadoxine and Pyrimethamine as an antimalarial agent.




Sulfadoxine and Pyrimethamine combination acts by reciprocal potentiation of its two components, achieved by a sequential blockade of two enzymes involved in the biosynthesis of folic acid in the parasites. Sulfadoxine and pyrimethamine is effective against strains of plasmodium falciparum that are resistant to chloroquine.



Both SuIfadoxine and Pyrimethamine are absorbed orally and are excreted mainly by the kidney. Following a single tablet administration, Sulfadoxine  peak plasma concentrations  of 51 to 76 mcg/ml are achieved in 2.5 to 6 hours and the Pyrimethamine peak plasma concentrations of 0.13 to 0.4 mcg/ml are achieved in 1.5 to 8 hours. The mean elimination half-life of Sulfadoxine is 169 hours whereas that of Pyrimethamine is 111 hours.



Treatment of P. falciparum malaria for those patients, in whom Choloroquine resistance is suspected.



Repeated use of Sulfadoxine and Pyrimethamine is contraindicated in patients with severe renal insufficiency, marked liver parenchymal damage or blood dyscrasias.

— Hypersensitivity to Pyrimethamine or Sulphonamides.

— Patients with documented megaloblastic anaemia due to Folate deficiency.

— Infants less than 2 months of age.

— Pregnancy at term and during nursing period.



Sulfadoxine and Pyrimethamine should be given with caution to patients with impaired renal or hepatic  function, to those with possible folate deficiency and to those with severe allergy or bronchial asthma, patients should be warned that at the first appearance of a skin rash, they should stop use of Sulfadoxine and Pyrimethamine and seek immediate medical attention.



There have been reports that incidence and severity of adverse effects may be increased by co-administering chloroquine with Sulfadoxine and Pyrimethamine. Antifolic drugs such as contrimoxazole should not be used while the patient is receiving the combination for antimalaria prophylaxis.



There are no adequate or well controlled studies in pregnant women. Since Sulphonamides are excreted in the human breast milk, the said combination is not recommended to nursing mothers.



Treatment of acute attack of malaria

A single dose of the following number of Pyrimethamine plus Sulfadoxine combination is used in sequence with quinine or alone.

Adults 2-3 tablets

9-14 years 2 tablets

4-8 years 1 tablet

Under 4 years ½ tablet

In Prophylaxis the above dosage to be taken every two weeks.



Store in a cool, dry place and keep away from reach of children. Protect from light.



50 x 3’s / 25 x 3’s / 1 x 3’s



March 2000


Manufactured by


92, SIPCOT, HOSUR-635 126, INDIA.



Waipa Compound Dihydroartemisinin Tablets


Compound Dihydroartemisinin Tablets



(3R-5aS, 6R, 8aS, 9R, 12S, 12Ar) – Eight hydro-3,6,9-trimethyl-3, 12-epoxy-12H-prano-[4,3-J] -1,2-benzodioxopine – 10(3H)-oI. (Dihydroartemisinin, DHA) AND 1,3 di[4-(7-chlorine-quinoIine-4-methyl-) piperazine-[-methyl] propone and tetradic phosphate (Piperaquine phosphate, PQP) combination.



Each tablet contains Dihydroartemisinin 30mg and Piperaquine Phosphate 225mg.



WAIPA is a novel excellent antimalarial drug with rapid action, high efficacy, low toxicity, high safety, strong inhibitory, gametocidal effect and short course for treatment of all forms of malaria, particularly for multi-drug resistant falciparum malaria.



Clinical trials showed that WAIPA has excellent efficacy to relieve clinical symptoms of malaria patients. Respectively, the average fever clearance time and parasite-clearance time is 16-20 hours and 24-50 hours. 98% of parasites are cleared within 24 hours, and 100% within 48 hours in the blood. The third day treatment is to clear the parasites from the liver. So, WAIPA prevents the re-occurrence of malaria for a long time and reduces the morbidity and mortality rates of malaria notably.



Recent clinical trials showed that 99.1% of malaria cases are cured and only 0.9% are recrudesced (re-occurred) after treatment with WAIPA during 28 days follow-up observations.



A 3-day treatment course reached very high cure rate.



Experiments on mice showed that there is no parameter changes on central nervous system, cardiovascular system, respiratory system and haematology, blood biochemistry after administration of WAIPA.



Experiments on mice showed that there is no parameter changes on central nervous system, cardiovascular system, respiratory system and haematology, blood biochemistry after administration of WAIPA.

WAIPA is very effective for Vivax malaria. It also has quick and high efficacy in killing vivax parasites and only 1.7% recrudesced as showed in clinical trials after 28 days.



Dihydroartemisinin (DHA): DHA is absorbed rapidly and completely, and distributed via circulation widely in kidney, lung, liver, spleen, bone, heart, muscle and brain, etc. 1 hour after oral administration.

Human pharmacokinetic parameters: Oral dosage 2mg/Kg, Tmax = 1 .33h, Cmax = 0.71 mg/ml, T ½ = 1.57h, 82.7% are excreted by urine and faeces and no primary combination was observed in 24 hours.

Piperaquine Phosphate (POP): 80-90% are absorbed in gastro-intestinal system and accumulated in liver, kidney, lung and spleen, etc. ¼ of the drug are accumulated in liver in 8 hours T ½ = 9 hours, T ½ 9hrs, Faeces and bile are the main excretion routes.



Researches showed the two components of WAIPA had synergism with potentiation of antimalarial effects and prevention of resistance to either Dihydroartemisinin and Piperaquine Phosphate.



Orally, take as shown below:

Adult (15 years and above): 4 tablets once daily for 3 days.

Children (8-14 years): 3 tablets once daily for 3 days.

Children (3-7 years): 2 tablets once daily for 3 days.

Children (0-2 years): ½ -1 Tablets once daily for 3 days.



Few cases of side effects occurred after administration of WAIPA, mainly caused by Piperaquine Phosphate, i.e. nausea 5.5%, vomiting 2.8%, inappetence 2.0%, belly ache 1.5%, diarrhoea 1.0%, dizziness 1.2%, itching 0.5% and rashes 0.1%.



This drug should be used carefully in pregnant women particularly in the first trimester and patients with liver diseases. This drug should not be taken repeatedly in four weeks after first treatment course.



12 tablets, each containing Dihydroartemisinin 30mg and Piperaquine Phosphate 225mg, packed in blisters.



Store in a cool, dry place and away from children.


Manufactured by


1, Adelanwa Street, Valley Estate,

Dopemu, Ikeja, Lagos, Nigeria,