Antiinflammatory, Antiedemic enzyme preparation.
Recently, according to the marked advances of enzymology, utilization of enzymes is expanded from the traditional animal enzymes to the plan and the microorganism enzymes. Enzyme preparation are used properly in a wide range of medicine also their exploitation enzymes. According to this tendency, KOTASE was developed as an enzyme preparation.
KOTASE combines primarily Bromelain, plant-proteolytic enzyme extracted from pineapple plant, Ananas comosus and Crystalline trypsin, animalproteolytic enzyme extracted from mammalian pancreas.
KOTASE is green sugar coated tablet and has potent antiinflammatory, antiedemic activity, after oral administration. Generally, inflammatory reaction occurs when abnormal change in body protein induces inflammatory polypeptide. Bromelain in KOTASE acts against inflammatory polypeptides such as bradykinin, kallidin etc. and crystalline trypsin acts against inflammatory polypeptides except kinis, therefore KOTASE actively breaks peptide bond, proteolytic action, it results effective antiinflammatory action.
KOTASE Tab, is a green and sugar coated tablet.
In each tab.
Bromeloin 20,000 units (40 mg)
Crystallized trypsin 2,500units (1 mg)
INDICATION AND USAGE
KOTASE Tab. may be indicated for the relief of symptoms related to inflammations such as edema, swelling, pain, eruption and resolutions of inflammation resulting from areolitis, thrombosis, hematoma, fracture distortion, internal hemorrhoids, external hemorrhoids, and prolapse, postoperative hemorrhoids.
DOSAGE AND ADMINISTRATION
Adults: Initially two tablets, tour times daily.
For maintenance one tablet, four times daily.
Appropriately reduce the dosage according to the age and the body weight.
1. Accompanying infections, proper antibiotics or chemotherapeutics may be used in combination
2. Contraindicated in patients with severe hepatic and renal functional disorder, peptic ulcer abnormalities of blood clotting, brown atrophy, progressive liver cirrhosis etc.
3. An occasional patient has experienced side effects such as diarrhoea, gastro intestinal disorders, local stimulating reactions (redness, pain), systemic reaction (fever, headache, nausea, vomiting).
Store in well-tight container.
100T, 500T, 1000T
KOREA PHARMA CO.,TD.
907-8 Sangshin-Ri Hyangnam-Exp, Hiwaseong-Dc, Korea.