Tovital Vitamin E Capsules

TOVITAL 1000®

Vitamin E Capsules USP 1000 IU

For the use of a Registered Medical Practitioner or a Hospital or a Laboratory only.

 

Composition

Each soft gelatin capsule contains:

Vitamin E USP 1000IU

(as dI-Alpha Tocopheryl acetate)

Excipients q.s.

 

Indication

Vitamin E is necessary in small amounts and is available in common foodstuffs like green leafy vegetables. Vitamin E prevents chemical oxidation, hence it acts mainly as an antioxidant. It is also important for the proper function of nerves and muscles. Vitamin E requirements are increased in intestinal disease, hepatic disease, pancreatic disorders and surgical removal of stomach. Prolonged treatment with vitamin E increases the survival time of erythrocytes in G-6-PD deficiency. The risk of retrolental fibroplasia in infants exposed to high concentrations of oxygen can be reduced by oral vitamin E.

 

Pharmacodynamic

Vitamin E deficiency has been linked to disorders such as cystic fibrosis where fat absorption is impaired. It is essential for the normal function of the muscular system and the blood.

 

Pharmacokinetics

Vitamin E is absorbed from the gastro-intestinal tract. Most appears in the lymph and is then widely distributed to all tissues. Most of a dose is slowly excreted in the bile and the remainder is eliminated in the urine as glucuronides of tocopheronic acid or other metabolites.

 

Recommended dose

Take one softgel capsule daily with meals or as directed by the physician.

 

Contraindication

Vitamin E may be contraindicated in bleeding disorders.

 

Warnings and Precautions

Tell your doctor about your medical history, especially of: allergies (including sulfa drugs), diabetes, high blood cholesterol or fats (lipids), liver or kidney disorders, blood disorders (hemophilia), digestive disorders (malabsorption). Caution is advised when this drug is used in the elderly as this group may be more prone to drug side effects. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk.

Avoid breast-feeding because breast milk can transmit HIV. Consult your doctor or pharmacist for more information.

 

Drug interactions

Vitamin E may impair the absorption of Vitamin A.

 

Pregnancy and Lactation

Trials have been conducted in pregnant women. The majority of trials report no increase in negative fetal outcome, but results regarding birth-weight are conflicting. Considering the evidence of harm (all-cause mortality), high-dose vitamin E supplementation should be used with caution. Natural food sources are preferred.

 

Undesirable effects

Overdoses (>1g) have been associated with minor side effects, including hypertension, fatigue, diarrhea and myopathy.

 

Overdose and treatment

Symptoms of overdose may include nausea, weakness, intestinal cramps, headache, flatulence, diarrhea, drowsiness, or loss of consciousness.

 

Storage condition

Store below 30°C. Protect from light and moisture.

 

Dosage forms and Packaging available

TOVITAL 1000 available as 10 capsules in a blister and 3 such blisters are packed in a carton.

 

Manufactured by

Softgel Healthcare Pvt. Ltd.,

Survey No. 20/1, Vandalur- Kelambakkam Road,

Pudupakkam Village, Kancheepuram District,

Tamilnadu – 603 103, India.

 

Manufactured for

BIOMEDICINE S.P.N.L.

No 16 Anionwu Street Odoakpu

Onitsha, Nigeria.

Sckivspharm@Yahoo.com

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Omogo

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