EMZOR ZINC SULPHATE 20mg TABLETS
Composition, Pharmacology, Indication, Dosage, Special warnings and precautions for use, Interactions with other medicinal products, Side effects, Overdose, Presentation, Storage and Manufacturer of Zinc Sulphate 20 Tablet Medicine for Diarrhoea.
Each tablet contains 54.8mg zinc sulphate monohydrate equivalent to 20mg of zinc.
Zinc is incompletely absorbed from the small bowel, with between 10 to 40% of an ingested dose absorbed. Numerous dietary components can interfere with zinc absorption, particularly phytates and fibre, which bind to zinc, resulting in poorly absorbed zinc complexes.
Approximately 60% of circulating zinc is bound to albumin and roughly 30% is bound to macroglobulin. The majority of zinc is stored in the liver and kidney, chiefly intracellularly, and bound to metalloproteins.
It has been estimated that approximately 0.5 to 1.0 mg/day is secreted in the biliary tract and excreted in the stool, while 0.5 to 0.8 mg/day is excreted in the urine.
Zinc-20 Tablet is indicated for the treatment of acute and persistent diarrhoea in infants and children up to 5 years of age.
Children: 6months-l2years: One tablet once daily for 10-14 days
Less than 6months: Half (1/2) tablet once daily or as prescribed by a Physician.
The tablet (or half tablet) should be dispersed completely in 1 teaspoon (5 ml) of clean water or breast milk and the entire amount administered orally to the child.
It is recommended that doses be administered between meals and a repeat dose be given if vomiting occurs within 30 minutes.
For missed doses, the missing dose can be taken as soon as possible, unless there is less than 6 hours until the next dose.
SPECIAL WARNINGS AND PRECAUTIONS FOR USE
Drugs which may inhibit zinc absorption, such as penicillamine, sodium valproate and ethambutol, should not be coadministered with Zinc-20 Tablets, unless the risks of discontinuation of the drug are judged to outweigh the benefit of zinc in treatment of the child’s diarrhoea.
INTERACTIONS WITH OTHER MEDICINAL PRODUCTS
When taken together, zinc may reduce the absorption of tetracyclines (but not doxycycline), and quinolone antibiotics. In addition, zinc may also interfere with the absorption of cephalexin or ceftibuten. An interval of at least three hours should be allowed between administration of zinc and any of these medicines.
Side effects of zinc are mild and transient. They include nausea, vomiting, and abdominal pain.
High doses of zinc cause emesis. In addition, zinc sulfate is corrosive at high doses, and may cause irritation and corrosion of the gastrointestinal tract, including ulceration of the stomach and possible perforation.
Treatment is primarily supportive, however induced emesis, gastric lavage, or activated charcoal may be useful in cases of substantial ingestions of zinc tablets. Chelating agents such as calcium disodium EDTA may be useful with the physcian’s prescription.
1×10’s, and 10×10’s Tablets
Store in a cool, dry place
Keep out of the reach of children.
Emzor Pharmaceuticals Industries Limited
Plot 3C, Block A, Aswani Market Road,
Oshodi-Apapa Express-way, Isolo, Lagos